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phrA [2018-10-05 18:45:52]
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phrA [2018-10-05 18:45:52]

response regulator aspartate phosphatase (RapA) inhibitor, control of the phosphorelay
locus
BSU12440
pI
10.23
mw
4.66 kDa
protein length
44 aa Sequence Blast
gene length
132 bp Sequence Blast
function
control of sporulation initiation
product
phosphatase (RapA) inhibitor
essential
no
synonyms
gsiAB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.6|Other protein controlling the activity of the phosphorelay]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.6|Other protein controlling the activity of the phosphorelay]
  • [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

    • Gene

    Coordinates
    1,316,995 → 1,317,129

    The protein

    Protein family

  • phr family (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|25D89EF3C4D57B3E6F9AB0210029651F74356906|rapA]-[gene|D31B325366D3F0169E4ECA8871645C7826019C10|phrA]
    description
    [Pubmed|1378051]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1378051], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]: repression, [Pubmed|14651647], in [regulon|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A regulon]
  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]) [Pubmed|16091051], in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]
  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|23569278,12618455], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|12850135], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]
    • view in new tab

    Biological materials

    Mutant

  • BKE12440 (Δ[gene|D31B325366D3F0169E4ECA8871645C7826019C10|phrA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE12440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTTAGATTTCATATAAACA, downstream forward: _UP4_TGATGCATAAAAAAAGACCC
  • BKK12440 (Δ[gene|D31B325366D3F0169E4ECA8871645C7826019C10|phrA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK12440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTTAGATTTCATATAAACA, downstream forward: _UP4_TGATGCATAAAAAAAGACCC

    • References

  • 8643670,8730857,11923303,1378051,14651647,12618455,12107147,19380751,16091051,20238180,27122155